Hashcash

http://en.wikipedia.org/wiki/Hashcash

Hashcash is a method of adding a textual stamp to the header of an email to prove the sender has expended a modest amount of CPU time calculating the stamp prior to sending the email. In other words, as the sender has taken a certain amount of time to generate the stamp and send the email, it is unlikely that they are a spammer. The receiver can, at negligible computational cost, verify that the stamp is valid. However, the only known way to find a header with the necessary properties is brute force, trying random values until the answer is found; though testing an individual string is easy, if satisfactory answers are rare enough it will require a substantial number of tries to find the answer.
The theory is that spammers, whose business model relies on their ability to send large numbers of emails with very little cost per message, cannot afford this investment into each individual piece of spam they send. Receivers can verify whether a sender made such an investment and use the results to help filter email.